The goal of Yeshiva University High School for Girls’ science program is to engage, excite, and inspire each student’s interest in the sciences, possibly as a future career, but more importantly as a vital component of everyday life. The Science Institute at YUHSG is a special research program that promotes the study of advanced science and mathematics. This highly innovative program gives select students the opportunity to concentrate their high school studies on scientific knowledge, science literacy, and research methodology. The students attend off-site lectures, participate in a research methodology course after school hours, and perform independent research. The Science Institute provides students with the opportunity to work with state-of-the-art technologies used in conducting original research, and prepares participants for summer research internships, and national and international science research competitions. This program was recognized with a $10,000 Toyota Tapestry grant from the National Science Teachers Association.